Major R&D Pipeline
As of February 7, 2025
(Updated based on quarterly financial disclosure)
-
●：Development progress from October 2024 onwards 〇：Development progress from April 2024 onwards
Neurology
Dementia
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| Disease | Study | Region | Development Stage | |
|---|---|---|---|---|
| 「Leqembi」(lecanemab/BAN2401) Treatment for Alzheimer’s disease (AD) / anti-Aβ protofibril antibody In-license (BioArctic AB) Injection (intravenous infusion, subcutaneous injection) Joint development with Biogen Inc. | ||||
| Early AD | 301 (Clarity AD) | Asia (South Korea) | ○ | Approval (April 2024) |
| UK | ○ | Approval (August 2024) | ||
| European Union | Submission (accepted: January 2023) | |||
| IV maintenance dosing for early AD (Additional Dosage and Administration) | 201／301 | US | ● | Approval (January 2025) |
| Maintenance dosing of a subcutaneous injection formulation for early AD (Additional Formulation) | 301 | US | ● | Submission (accepted: January 2025) |
| Preclinical AD | 303 (AHEAD 3-45) | Japan/US/Europe | 笔Ⅲ | |
| E2814 anti-MTBR tau antibody Collaboration (University College London) Injection | ||||
| Dominantly inherited AD (in combination with lecanemab) | Tau Nexgen | JP/US/EU | 笔Ⅱ/Ⅲ | |
| Dominantly inherited AD | 103 | US/EU | 笔Ⅰ产/Ⅱ | |
| Sporadic early AD (in combination with lecanemab) | 202 | JP/EU | ○ | PⅡ |
| E2511 TrkA integrated synapse regenerant 滨苍-丑辞耻蝉别 翱谤补濒 | ||||
| AD | - | US | 笔Ⅰ | |
| E2025 Anti-EphA4 antibody 滨苍-丑辞耻蝉别 滨苍箩别肠迟颈辞苍 | ||||
| AD | - | US | 笔Ⅰ | |
Neurological diseases other than dementia
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| Disease | Study | Region | Development Stage | |
|---|---|---|---|---|
| 「Fycompa」(perampanel/E2007) Antiepileptic agent / AMPA receptor antagonist 滨苍-丑辞耻蝉别 翱谤补濒 / Injection | ||||
| Adjunctive therapy for primary generalized tonic-clonic seizures (Additional Indication) | 332 | China | ○ | Approval (April 2024) |
| 「Dayvigo」(lemborexant/E2006) Insomnia treatment / Orexin receptor antagonist 滨苍-丑辞耻蝉别 翱谤补濒 | ||||
| Insomnia disorder | 311 | China | Submission (accepted: January 2024) | |
| 「Rozebalamin」(mecobalamin/E0302) Treatment for Amyotrophic lateral sclerosis (ALS) 滨苍-丑辞耻蝉别 滨苍箩别肠迟颈辞苍 | ||||
| ALS | JETALS (IIS) | Japan | ○ | Approval (September 2024) |
| E2086 Orexin receptor agonist 滨苍-丑辞耻蝉别 翱谤补濒 | ||||
| Narcolepsy | - | US | 笔Ⅰb | |
Oncology
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| Disease | Study | Region | Development Stage | |
|---|---|---|---|---|
| 「Lenvima/Kisplyx」(lenvatinib/E7080) Anticancer agent / kinase inhibitor 滨苍-丑辞耻蝉别 翱谤补濒 | ||||
| In combination with anti-PD-1 therapy pembrolizumab, joint development with Merck & Co., Inc., Rahway, NJ, USA, through an affiliate (Additional Indication) | ||||
| Hepatocellular carcinoma (in combination with transcatheter arterial chemoembolization) | LEAP-012 | JP/US/EU/CH | 笔Ⅲ | |
| Esophageal carcinoma (in combination with chemotherapy) / First-line | LEAP-014 | JP/US/EU/CH | 笔Ⅲ | |
| Gastric cancer (in combination with chemotherapy) / First-line | LEAP-015 | JP/US/EU/CH | 笔Ⅲ | |
| In combination with anti-PD-1 antibody nivolumab, joint development with Ono Pharmaceutical (Additional Indication) | ||||
| Hepatocellular carcinoma | - | Japan | 笔Ⅰb | |
| 「Halaven」(eribulin/E7389) Anticancer agent / microtubule dynamics inhibitor 滨苍-丑辞耻蝉别 滨苍箩别肠迟颈辞苍 | ||||
| Monotherapy (Additional Formulation) | ||||
| Liposomal formulation | - | JP/EU | 笔Ⅰ | |
| In combination with anti-PD-1 antibody nivolumab, joint development with Ono Pharmaceutical (Additional Formulation) | ||||
| Liposomal formulation | 120 | Japan | 笔Ⅰ产/Ⅱ | |
| 「Tasfygo」(tasurgratinib/E7090) Anticancer agent / FGFR1, FGFR2, FGFR3 inhibitor 滨苍-丑辞耻蝉别 翱谤补濒 | ||||
| Biliary tract cancer with FGFR2 gene fusion | 201 | Japan | ○ | Approval (September 2024) |
| Breast cancer | - | Japan | 笔Ⅰb | |
| farletuzumab ecteribulin（FZEC）/MORAb-202 Anticancer agent / Folate receptor α targeted antibody drug conjugate 滨苍-丑辞耻蝉别 滨苍箩别肠迟颈辞苍 | ||||
| Non-small cell lung cancer | 203 | US/EU | 笔Ⅱ | |
| Ovarian cancer, peritoneal cancer, fallopian tube cancer | 205 | JP/US/EU | 笔Ⅱ | |
| Solid tumors | 201 | US/EU | 笔Ⅰ/Ⅱ | |
| E7386 Anticancer agent / CBP/β-catenin interaction inhibitor Collaboration (PRISM BioLab) Oral | ||||
| Solid tumors (in combination with pembrolizumab) | 201 | JP/US/EU | 笔Ⅰ产/Ⅱ | |
| Solid tumors (in combination with lenvatinib) | 102 | JP/US/EU | 笔Ⅰ产/Ⅱ | |
| Solid tumors | - | JP/US/EU | 笔Ⅰ | |
| H3B-6545 Anticancer agent / ERα inhibitor 滨苍-丑辞耻蝉别 翱谤补濒 | ||||
| Breast cancer (in combination with CDK4/6 inhibitor palbociclib) | - | US/EU | 笔Ⅰb | |
| E7130 Anticancer agent Collaboration (Harvard University) Injection | ||||
| Solid tumors | - | Japan | 笔Ⅰ | |
| E7766 Anticancer agent 滨苍-丑辞耻蝉别 滨苍箩别肠迟颈辞苍 | ||||
| Solid tumors | - | US/EU | 笔Ⅰb | |
Global Health
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| Disease | Sponsor of study | Region | Development Stage | |
|---|---|---|---|---|
| fosravuconazole/E1224 Antifungal agent / ergosterol synthesis inhibitor 滨苍-丑辞耻蝉别 翱谤补濒 | ||||
| Eumycetoma *Supported by GHIT fund *吃瓜大赛黑料头条 is mainly responsible for non-clinical studies and the provision of the investigational drug. |
DNDi?Mycetoma Research Center of the University of Khartoum | Sudan | 笔Ⅱb/Ⅲ | |
| SJ733 Antimalarial agent / ATP4 inhibitor Co-development (University of Kentucky) Oral | ||||
| Malaria *Supported by GHIT fund *吃瓜大赛黑料头条 is responsible for the provision of drug substance and formulation manufacturing |
University of Kentucky | Peru | 笔Ⅱ | |
| AWZ1066S Antifilarial agent / antiwolbachia mechanism Co-development (Liverpool School of Tropical Medicine) Oral | ||||
| Lymphatic filariasis / onchocerciasis (river blindness) *Supported by the GHIT Fund and Medical Research Council in the UK *吃瓜大赛黑料头条 is responsible for the provision of drug substance and formulation manufacturing |
Liverpool School of Tropical Medicine | UK | 笔Ⅰ | |
Gastrointestinal Disorders
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| Disease | Study | Region | Development Stage | |
|---|---|---|---|---|
| MOVICOL/(AJG555) Chronic constipation treatment / polyethylene glycol preparation In-license (Norgine) Oral | ||||
| Chronic constipation in children under 2 years of age (Additional Dosage and Administration) (Development conducted by EA Pharma) | CT3 | Japan | 笔Ⅲ | |
| AJM347 滨苍-丑辞耻蝉别 翱谤补濒 | ||||
| Inflammatory bowel disease (Joint development conducted by EA Pharma with Ensho Therapeutics, Inc) | - | EU | 笔Ⅰ | |
| EA1080 滨苍-丑辞耻蝉别 翱谤补濒 | ||||
| Inflammatory bowel disease (Joint development conducted by EA Pharma with Ensho Therapeutics, Inc) | - | EU | 笔Ⅰ | |
| EA3571 滨苍-丑辞耻蝉别 翱谤补濒 | ||||
| Metabolic dysfunction-associated steatohepatitis (Development conducted by EA Pharma) | - | Japan | 笔Ⅰ | |
Other
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| Disease | Study | Region | Development Stage | |
|---|---|---|---|---|
| dotinurad / FYU-981 Treatment for Hyperuricemia and Gout / selective URAT1 inhibitor In-license (FUJI YAKUHIN) Oral | ||||
| Gout, hyperuricemia | - | Asia (Thailand) |
○ |
Approval (September 2024) |
| Gout | 301 | China | ● | Approval (December 2024) |
| E6742 Treatment for Systemic lupus erythematosus / TLR 7/8 inhibitor 滨苍-丑辞耻蝉别 翱谤补濒 | ||||
| Systemic lupus erythematosus | 101 | Japan | 笔Ⅰ/Ⅱ | |
| E8001 In house Injection | ||||
| Rejection reaction associated with organ transplantation | - | Japan | 笔Ⅰ | |